Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq.

@article{Islam2011CharacterizationOT,
  title={Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq.},
  author={Saiful Islam and Una Kj{\"a}llquist and A. Moliner and Pawel Zajac and Jian-Bing Fan and Peter L{\"o}nnerberg and Sten Linnarsson},
  journal={Genome research},
  year={2011},
  volume={21 7},
  pages={1160-7}
}
Our understanding of the development and maintenance of tissues has been greatly aided by large-scale gene expression analysis. However, tissues are invariably complex, and expression analysis of a tissue confounds the true expression patterns of its constituent cell types. Here we describe a novel strategy to access such complex samples. Single-cell RNA-seq expression profiles were generated, and clustered to form a two-dimensional cell map onto which expression data were projected. The… CONTINUE READING
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