Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays.

@article{Trambas2018CharacterizationOT,
  title={Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays.},
  author={Christina M Trambas and Zhong Xian Lu and Tina Yen and Kenneth Andrew Sikaris},
  journal={Annals of clinical biochemistry},
  year={2018},
  volume={55 2},
  pages={
          205-215
        }
}
Background Biotin interference is a significant problem to which at-risk laboratories must now be attuned. We sought to systematically characterize the nature of this interference in Roche immunoassays. Methods Known concentrations of biotin were titrated into serum samples and the effects on competitive and sandwich immunoassays were analysed. The maximum and minimum concentrations examined reflect those likely to be achieved in individuals on 5 to 10 mg supplements at the lower end, and 100… CONTINUE READING
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