Characterization of the rhesus cytomegalovirus US28 locus.

  title={Characterization of the rhesus cytomegalovirus US28 locus.},
  author={Mark E.T. Penfold and Thortsen L Schmidt and Daniel J. Dairaghi and Peter A. Barry and Thomas J. Schall},
  journal={Journal of virology},
  volume={77 19},
Human cytomegalovirus (CMV) US28 (and the related open reading frame [ORF] US27) are G-protein-coupled receptor homologs believed to play a role in viral pathogenesis. In vitro, US28 has been shown to bind and internalize ligands, as well as activate intracellular signaling in response to certain chemokines, and to initiate the migration of smooth muscle cells to chemokine gradients. To assess the role of US28 in vivo, we examined the rhesus model and sequenced and characterized the rhesus CMV… CONTINUE READING
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