Characterization of the reverse Na/Ca exchange in squid axons and its modulation by Cai and ATP. Cai-dependent Nai/Cao and Nai/Nao exchange modes

@article{Dipolo1987CharacterizationOT,
  title={Characterization of the reverse Na/Ca exchange in squid axons and its modulation by Cai and ATP. Cai-dependent Nai/Cao and Nai/Nao exchange modes},
  author={Reinaldo Dipolo and Luis A Beaug{\'e}},
  journal={The Journal of General Physiology},
  year={1987},
  volume={90},
  pages={505 - 525}
}
We have used dialyzed squid axons to characterize the ouabain- and bumetanide-insensitive Na efflux components and their relation to the operation of the Na/Ca exchange mechanism. In axons dialyzed with solutions containing nearly physiological concentrations of K, Na, and Mg, three components of the Na efflux can be distinguished: Cai-activated, Cao-dependent Na efflux ("reverse" Na/Ca exchange); Cai-activated, Nao-dependent Na efflux; and Cai-independent, ATP-activated, Nao-dependent Na… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Towards Understanding the Role of the Na²⁺-Ca²⁺ Exchanger Isoform 3.

Reviews of physiology, biochemistry and pharmacology • 2015
View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Ca ~ + i requirement for the outward membrane current associated with the reversal of the Na / Ca exchange

R. DiPolo, C. Caputo, F. Bezanilla
Biophysical Journal . • 1987

Demonstration of NaCa exchange asymmetry in squid optic nerve vesicles

R. DiPolo
Biophysical Journal . • 1987

Reverse NaCa exchange requires internal Ca and / or ATP in squid axons

R. DiPolo, F. Bezanilla, C. Caputo, H. Rojas
Biochima et Biophysica Acta . • 1986

The sarcolemma sodium - calcium exchange system

J. M. Russell
Current Topics in Membranes and Transport . • 1986

Effect of internal and external K + on Na + - Ca 2 + exchange in dialyzed squid axons under voltage clamp conditions

H. Rojas
Biochimica et Biophysica Acta . • 1984
View 1 Excerpt

The regulation of the Na § 2 + exchanger of heart sarcolemma

P. E. Hoar
European Journal of Biochemistry . • 1983

Ca influx in internally dialyzed squid axons

R. DiPolo, L. Beaug
Journal of General Physiology . • 1979

Similar Papers

Loading similar papers…