Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene.

@article{Hocher1996CharacterizationOT,
  title={Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene.},
  author={Berthold Hocher and Lutz Liefeldt and Christa Th{\"o}ne-Reineke and Hans D Orzechowski and Armin Distler and C. S. Bauer and Martin Paul},
  journal={Hypertension},
  year={1996},
  volume={28 2},
  pages={196-201}
}
We have previously established a transgenic rat model termed TGR(hET-2)37 overexpressing the human endothelin-2 (ET-2) gene with high renal transgene expression. This renal overexpression is of pathophysiological interest because a long-term activated paracrine renal endothelin system has been implicated in chronic renal failure due to progressive glomerular injury. Therefore, our aim in the present study was to analyze renal transgene expression in detail and address the question of whether… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…