Characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product.

@article{Smith1992CharacterizationOT,
  title={Characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product.},
  author={Robert H. Smith and Gretchen B. Caughman and D J O'callaghan},
  journal={Journal of virology},
  year={1992},
  volume={66 2},
  pages={936-45}
}
Use of the translation-inhibiting drug cycloheximide has indicated that the equine herpesvirus 1 (EHV-1) immediate-early (IE) gene, the sole EHV-1 IE gene, encodes a major viral regulatory protein since IE mRNA translation is a prerequisite for all further viral gene expression (W.L. Gray, R. P. Baumann, A. T. Robertson, G. B. Caughman, D. J. O'Callaghan, and J. Staczek, Virology 158:79-87, 1987). An EHV-1 IE gene expression vector (pSVIE) in combination with chimeric EHV-1 promoter… CONTINUE READING
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