Characterization of the reciprocal binding sites on human alpha-thrombin and factor XIII A-chain.

Abstract

Solution- and solid-phase techniques were used to probe Factor XIII A-chain-alpha-thrombin interactions. Alpha-thrombin activated Factor XIII more efficiently (Km = 0.83 +/- 0.08 x 10(-7) M; V/K = 14.90 +/- 3.20 x 10(-3) min(-1)) than beta-thrombin (Km = 6.14 +/- 1.26 x 10(-7) M; V/K = 3.30 +/- 1.00 x 10(-3) min(-1)) or gamma-thrombin (Km = 6.25 +/- 1.15 x… (More)

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Cite this paper

@article{Achyuthan1998CharacterizationOT, title={Characterization of the reciprocal binding sites on human alpha-thrombin and factor XIII A-chain.}, author={Komandoor E. Achyuthan}, journal={Molecular and cellular biochemistry}, year={1998}, volume={178 1-2}, pages={289-97} }