Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.

@article{Misu2013CharacterizationOT,
  title={Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.},
  author={Ryosuke Misu and Shinya Oishi and Shohei Setsuda and Taro Noguchi and Masato Kaneda and Hiroaki Ohno and Barry T. Evans and J. M. Navenot and Stephen C. Peiper and Nobutaka Fujii},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 9},
  pages={
          2628-31
        }
}
  • Ryosuke Misu, Shinya Oishi, +7 authors Nobutaka Fujii
  • Published in
    Bioorganic & medicinal…
    2013
  • Chemistry, Medicine
  • Kisspeptins, endogenous peptide ligands for GPR54, play an important role in GnRH secretion. Since in vivo administration of kisspeptins induces increased plasma LH levels, GPR54 agonists hold promise as therapeutic agents for the treatment of hormonal secretion diseases. To facilitate the design of novel potent GPR54 ligands, residues in kisspeptins that involve in the interaction with GPR54 were investigated by kisspeptin-based photoaffinity probes. Herein, we report the design and synthesis… CONTINUE READING

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