Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.

Abstract

The target of rapamycin complex 1 (TORC1) is an essential multiprotein complex conserved from yeast to humans. Under favorable growth conditions, and in the absence of the macrolide rapamycin, TORC1 is active, and influences virtually all aspects of cell growth. Although two direct effectors of yeast TORC1 have been reported (Tap42, a regulator of PP2A… (More)
DOI: 10.1101/gad.532109

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@article{Huber2009CharacterizationOT, title={Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.}, author={Alexandre Huber and Bernd Bodenmiller and Aino Uotila and Michael Stahl and Stefanie Wanka and Bertran Gerrits and Ruedi Aebersold and Robbie J Loewith}, journal={Genes & development}, year={2009}, volume={23 16}, pages={1929-43} }