Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase.

@article{Nanjundan2000CharacterizationOT,
  title={Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase.},
  author={Meera Nanjundan and Fred Possmayer},
  journal={Experimental lung research},
  year={2000},
  volume={26 5},
  pages={361-81}
}
Phosphatidate phosphohydrolase (PAPase) is a key enzyme involved in glycerolipid synthesis where it converts phosphatidic acid to diacylglycerol. Previous studies performed in lung have demonstrated the existence of 2 different forms of PAPases, namely PAP-1 and PAP-2. The former pulmonary Mg+2-dependent enzyme is N-ethylmaleimide (NEM)-sensitive, heat labile, and is involved in phospholipid biosynthesis. However, the function of the latter lung isozyme is unknown. PAP-2 activity was… CONTINUE READING