Characterization of the proximal estrogen-responsive element of human cathepsin D gene.

@article{Augereau1994CharacterizationOT,
  title={Characterization of the proximal estrogen-responsive element of human cathepsin D gene.},
  author={Patrick Augereau and F Miralles and Vincent Cavaill{\`e}s and C Gaudelet and Martyn Parker and Henri Rochefort},
  journal={Molecular endocrinology},
  year={1994},
  volume={8 6},
  pages={693-703}
}
Cathepsin D, a lysosomal proteinase, is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis. Its gene expression is stimulated by estrogens in MCF7 cells, and we have shown that a short proximal promoter fragment from -365 to -122 is required for this induction. We now characterize, at -261, a nonconsensus estrogen-responsive element (ERE) (E2) with two differences in the distal half of its palindrome, which confers estradiol… CONTINUE READING

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