Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding.

Abstract

As part of a study to examine cocaine disposition and interaction with ethanol, it was necessary to characterize various properties of cocaine in the blood of the experimental animal. All studies were conducted using blood from healthy adult male Sprague-Dawley rats. Cocaine was incubated in whole blood at 37 degrees C at concentrations of 500-4000 ng/mL… (More)

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@article{Sukbuntherng1996CharacterizationOT, title={Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding.}, author={Juthamas Sukbuntherng and D. K. Martin and Y{\"u}cel Pak and Michael Mayersohn}, journal={Journal of pharmaceutical sciences}, year={1996}, volume={85 6}, pages={567-71} }