Characterization of the promoter region of the human c-erbB-2 protooncogene.

  title={Characterization of the promoter region of the human c-erbB-2 protooncogene.},
  author={Seiji Ishii and Fumio Imamoto and Yoshihide Yamanashi and Kumao Toyoshima and Toshiyuki Yamamoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 13},
Three overlapping genomic clones that contain the 5'-terminal portion of the human c-erbB-2 gene (ERBB2) were isolated. The promoter region was identified by nuclease S1 mapping with c-erbB-2 mRNA. Seven transcriptional start sites were identified. DNA sequence analysis showed that the promoter region contains a "TATA box" and a "CAAT box" about 30 and 80 base pairs (bp), respectively, upstream of the most downstream RNA initiation site. Two putative binding sites for transcription factor Sp1… CONTINUE READING
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