Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.

@article{Chou1991CharacterizationOT,
  title={Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.},
  author={Jia‐ling Chou and Richard F. Rozmahel and Lap Chee Tsui},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 36},
  pages={24471-6}
}
To identify the transcription regulatory elements of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, DNA fragments located in the 5'-upstream region were fused with the bacterial chloramphenicol acetyltransferase (CAT) reporter gene and transfected into various cell lines to test for promoter activity. The results of these studies suggested that there were at least two positive and one negative cisacting elements involved in CFTR transcription initiation. One of them was a… CONTINUE READING

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