Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.

@article{Khanna2006CharacterizationOT,
  title={Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.},
  author={S. Sampath Khanna and Sashwati Roy and Narasimham L. Parinandi and Mariah Maurer and Chandan K. Sen},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 5},
  pages={
          1474-86
        }
}
The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissect the antioxidant-independent and -dependent neuroprotective properties of alpha-tocotrienol by using two different triggers of neurotoxicity, homocysteic acid (HCA) and linoleic… CONTINUE READING

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