Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists

Abstract

Antagonists of adenosine A2A receptors (A2A-antagonists) with different chemical structures have been developed by several pharmaceutical companies for the potential treatment of Parkinson’s disease. Pharmacological characterization of these antagonists was incomplete, and different assay conditions were used in different labs. Therefore, we characterized… (More)
DOI: 10.1007/s00210-007-0135-0

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