Characterization of the phosphatidylserine-exposing subpopulation of sickle cells.

@article{Jong2001CharacterizationOT,
  title={Characterization of the phosphatidylserine-exposing subpopulation of sickle cells.},
  author={Kitty de Jong and Sandra K. Larkin and Lori A Styles and Robert M. Bookchin and Frans A. Kuypers},
  journal={Blood},
  year={2001},
  volume={98 3},
  pages={
          860-7
        }
}
Phosphatidylserine (PS), exclusively present in the inner monolayer of the normal red blood cell (RBC) membrane, is exposed in subpopulations of sickle cells. PS-exposing RBCs were found predominantly among the densest and the very light sickle cells. Within the light RBC fraction, PS exposure was found on reticulocytes, transferrin receptor-expressing reticulocytes, and mature RBCs. The last subset contained low-density valinomycin-resistant RBCs, previously shown to have high Na(+) and low K… CONTINUE READING

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Increased RBC phosphatidylserine exposure in sickle cell disease patients at risk for stroke by transcranial Doppler screening [abstract

LA Styles, K De Jong, E Vichinsky
  • 1997

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