Characterization of the pharmacokinetic interaction between nifedipine and ethanol in the rat.

@article{Boje1989CharacterizationOT,
  title={Characterization of the pharmacokinetic interaction between nifedipine and ethanol in the rat.},
  author={Kathleen M. K. Boje and H. L. Fung},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={249 2},
  pages={567-71}
}
We characterized the pharmacokinetic interaction between nifedipine and ethanol as a function of route of administration with pharmacokinetic monitoring of both compounds. Nifedipine was infused (8.5 micrograms/min/kg) for 9 hr either i.a. or intraportally to assess the extent of hepatic first-pass metabolism of nifedipine in the rat. Nifedipine clearance and volume of distribution were similar for both routes of administration. Thus, hepatic first-pass metabolism of nifedipine was apparently… CONTINUE READING