Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins.

@article{Veniamin2011CharacterizationOT,
  title={Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins.},
  author={Simona M. Veniamin and Luanne G Sawatzky and Graham S. Banting and D. Moira Glerum},
  journal={Free radical biology \& medicine},
  year={2011},
  volume={51 8},
  pages={
          1589-600
        }
}
The mitochondrial copper chaperone COX11 plays an auxiliary role in the defence against oxidative stress
TLDR
Evidence is presented that this protein is also involved in the defence against reactive oxygen species by directly or indirectly exploiting the redox capacity of their cysteine residues, and yeast strains overexpressing soluble versions of either AtCOX11 or Sc COX11 became more resistant against oxidative stress.
The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis
TLDR
Results suggest that COX11 homologs, in addition to participating in COX complex assembly, have a distinct and evolutionary conserved role in protecting cells during heightened oxidative stress.
The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly*
TLDR
Pet117 mediates coupling of heme a synthesis to the CcO assembly process in eukaryotes and physically interacts with Cox15 and specifically mediates the stability of Cox15 oligomeric complexes.
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS
TLDR
In conditions of increased oxidative stress, APOPT1 is stabilized, increasing its mature intramitochondrial form and thereby protecting COX from oxidatively induced degradation, and levels were shown to be controlled by the ubiquitination–proteasome system (UPS).
OsNAC2 positively affects salt‐induced cell death and binds to the OsAP37 and OsCOX11 promoters
TLDR
It is suggested that OsNAC2 accelerates NaCl-induced PCD and provide new insights into the mechanisms that affect ROS accumulation, plant caspase-like activity, and K+ efflux.
Redox and reactive oxygen species regulation of mitochondrial cytochrome C oxidase biogenesis.
TLDR
Forthcoming insights into the precise regulation of mitochondrial COX biogenesis in normal and stress conditions will likely open future perspectives for understanding mitochondrial redox regulation and prevention of oxidative stress.
Mechanisms of mitochondrial translational regulation
TLDR
The author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field.
Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells
TLDR
The role that redox regulation plays in the maintenance of IMS homeostasis is discussed as well as how mitochondrial ROS generation may be a key regulatory factor for ETC biogenesis, especially for complex IV.
Coordination of metal center biogenesis in human cytochrome c oxidase
TLDR
It is reported that in human cells the CcO copper chaperones form macromolecular assemblies and cooperate with several twin CX9C proteins to control heme a biosynthesis and coordinate copper transfer sequentially to the CuA and CuB sites.
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TLDR
Results are consistent with the previously proposed function of Cox17p, namely in providing cytoplasmic copper for mitochondrial utilization.
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TLDR
These studies provide the first evidence at the level of the cytochrome oxidase holoenzyme that Cox1p is the in vivo target for Cox11p and suggest that Cox 11p may also have a role in the response to hydrogen peroxide exposure.
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TLDR
Evidence is presented indicating that Cox17p is not involved in general copper metabolism in yeast but rather has a more specific function in the delivery of copper to mitochondria.
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TLDR
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TLDR
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TLDR
The steady-state level of mutant Sco1 was severely decreased in the muscle mitochondria of the SCO1 patient, indicating compromised stability and thus loss of function of the protein, and a fraction of Sco1 physically associates with the CcO complex in human Muscle mitochondria, suggesting a possible direct relationship between Cc O and the regulation of cellular copper homeostasis.
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TLDR
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Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3.
TLDR
The existence in yeast of a second nuclear gene, COX11, whose encoded protein is homologous to another open reading frame (ORF3) present in the same operon of P. denitrificans is demonstrated.
SCO1, a yeast nuclear gene essential for accumulation of mitochondrial cytochrome c oxidase subunit II
TLDR
Analysis of the mitochondrial translation products in a sco1-1 mutant reveals a strong reduction in CoxII, indicating that the SCO1 gene product must be involved in a post-transcriptional step in the synthesis of CoxII.
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