Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist.

@article{Hahn1982CharacterizationOT,
  title={Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist.},
  author={Richard A. Hahn and Joe R. Wardell and Henry M. Sarau and Peter T. Ridley},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={223 2},
  pages={305-13}
}
SK&F 82526 (6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-(1H)-3-benzazepine) was evaluated for its peripheral cardiovascular activity, effect on renal and central dopamine receptors and mechanism of action. Comparisons were made with dopamine. In anesthetized dogs, SK&F 82526 i.v., produced dose-related dilation of the renal vasculature, apparently through stimulation of postsynaptic dopamine receptors. Unlike dopamine, the increased renal perfusion was not accompanied by… CONTINUE READING

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