Characterization of the palmitoylation domain of SNAP-25.

@article{Lane1997CharacterizationOT,
  title={Characterization of the palmitoylation domain of SNAP-25.},
  author={Steven R. Lane and Yun Liu},
  journal={Journal of neurochemistry},
  year={1997},
  volume={69 5},
  pages={
          1864-9
        }
}
SNAP-25 (synaptosomal associated protein of 25 kDa) is a neural specific protein that has been implicated in the synaptic vesicle docking and fusion process. It is tightly associated with membranes, and it is one of the major palmitoylated proteins found in neurons. The functional role of palmitoylation for SNAP-25 is unclear. In this report, we show that the palmitate of SNAP-25 is rapidly turned over in PC12 cells, with a half-life of approximately 3 h, and the half-life for the protein is 8… CONTINUE READING

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