Characterization of the p53-dependent postmitotic checkpoint following spindle disruption.

@article{Lanni1998CharacterizationOT,
  title={Characterization of the p53-dependent postmitotic checkpoint following spindle disruption.},
  author={J S Lanni and Tyler 8 Jacks},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 2},
  pages={
          1055-64
        }
}
The p53 tumor suppressor gene product is known to act as part of a cell cycle checkpoint in G1 following DNA damage. In order to investigate a proposed novel role for p53 as a checkpoint at mitosis following disruption of the mitotic spindle, we have used time-lapse videomicroscopy to show that both p53+/+ and p53-/- murine fibroblasts treated with the spindle drug nocodazole undergo transient arrest at mitosis for the same length of time. Thus, p53 does not participate in checkpoint function… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 205 CITATIONS, ESTIMATED 58% COVERAGE

352 Citations

01020'98'03'09'15
Citations per Year
Semantic Scholar estimates that this publication has 352 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…