Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV).

@article{Rucci2002CharacterizationOT,
  title={Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV).},
  author={Nadia Rucci and Silvia Migliaccio and Bianca Maria Zani and Anna Taranta and Anna Maria Teti},
  journal={Journal of cellular biochemistry},
  year={2002},
  volume={85 1},
  pages={167-79}
}
Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calculated gravity of 0.008g. For comparison, aliquots of cells were grown in conventional tissue culture dishes or in Non-Rotating Wall Vessels (N-RWV) maintained at unit gravity. In… CONTINUE READING

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