Characterization of the oral absorption of beta-lactam antibiotics. II. Competitive absorption and peptide carrier specificity.


The beta-lactam antibiotic oral absorption pathway is studied using a single-pass perfusion technique in the rat small intestine. Beta-lactam antibiotic absorption in the presence of amino acids, small peptides, and other beta-lactams is modeled using a simple competitive inhibition boundary condition at the intestinal wall, with a corrected value for the… (More)


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