Characterization of the normal progesterone and placental protein 14 responses to human chorionic gonadotropin stimulation in the luteal phase.

@article{Batista1994CharacterizationOT,
  title={Characterization of the normal progesterone and placental protein 14 responses to human chorionic gonadotropin stimulation in the luteal phase.},
  author={Marcelo C. Batista and Tannia P. Cartledge and Lynnette K Nieman and N Bravo and D. Lynn Loriaux and George R. Merriam},
  journal={Fertility and sterility},
  year={1994},
  volume={61 4},
  pages={
          637-44
        }
}
Circulating concentrations of placenta protein 14 during the natural menstrual cycle in women significantly reflect endometrial receptivity to implantation and pregnancy during successive assisted reproduction cycles.
TLDR
It is concluded that circulating PP14 is a most reliable biochemical marker of endometrial function in women and that relatively low concentrations in serum during the natural, unstimulated cycle are significantly correlated to implantation and pregnancy during successive assisted reproduction cycles.
Circulating concentrations of placenta protein 14 during the natural menstrual cycle in women significantly reflect endometrial receptivity to implantation and pregnancy during successive assisted reproduction cycles
TLDR
It is concluded that circulating PP14 is a most reliable biochemical marker of endometrial function in women and that relatively low concentrations in serum during the natural, unstimulated cycle are significantly correlated to implantation and pregnancy during successive assisted reproduction cycles.
Serum glycodelin pattern during the menstrual cycle in healthy young women
TLDR
Normal values taken at two‐ or one‐day intervals demonstrate the very late appearance of high serum glycodelin levels during the physiological menstrual cycle and their correlation with progesterone occurring earlier in the cycle.
The role of relaxin in glycodelin secretion.
TLDR
The data demonstrate that relaxin can stimulate gly codelin secretion throughout the menstrual cycle, including the periovulatory period, when relaxin-induced glycodelin secretion could have a contraceptive effect.
Endometrial and fetoplacental markers in pregnancies with fetal congenital nephrosis
TLDR
This work studied whether concentrations of other pregnancy‐related markers offer any ancillary procedure for screening, and found that maternal serum alpha‐fetoprotein [MSAFP], elevated amniotic fluid [AF] AFP being the only diagnostic test in population screening.
LUTEAL PHASE DEFICIT AND PROGESTERONE SUPPLEMENTATION
TLDR
The main causes of the LPD at the unstimulated cycles are considered poor follicle production from the ovary, premature exhaustion of the corpus luteum, and weakness of the inner layers of the uterus to respond on the normal concentrations of progesterone.
Assessment of the luteal phase in stimulated and substituted cycles
  • H. Fatemi
  • Biology, Medicine
    Facts, views & vision in ObGyn
  • 2009
TLDR
GnRH isunique among releasing hormones in that it simultaneously regulates the secretion of two hormonesFSH and LH and also is unique among the body’s hormones because it must be secreted in a Assessment of the luteal phase in stimulated and substituted cycles.

References

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Serum Levels of Placental Protein 14 Do Not Accurately Reflect Histologic Maturation of the Endometrium
TLDR
Serum measurements of placental protein 14 do not accurately predict, and thus should not replace, histologic evaluation of the endometrium at nidation, and both the integrated secretion of this protein and single measurements on the day of the biopsy or at the onset of the next menses overlapped substantially in women with different degrees of endometrial development.
Progesterone and human chorionic gonadotropin do not stimulate placental proteins 12 and 14 or prolactin production by human decidual tissue in vitro.
TLDR
It is concluded that PP14 is mainly produced by decidual gland cells, and progesterone at the concentrations used in this study does not stimulate production of PP12, PP14, and PRL in decidUALized endometrium in vitro.
Human corpus luteum: luteinizing hormone and chorionic gonadotropin receptors during the menstrual cycle.
TLDR
In normal CL, total and unoccupied LH/hCG receptor levels parallel progesterone secretion; changes in the binding affinity may be important in sustaining and/or rescuing the CL; and loss of LH/ hCG receptors is probably related to luteolysis.
The hCG test: an approach to luteal insufficiency.
  • I. Gerhard, B. Runnebaum
  • Medicine, Biology
    European journal of obstetrics, gynecology, and reproductive biology
  • 1982
A biochemical test for the direct assessment of endometrial function: measurement of the major secretory endometrial protein PP14 in serum during menstruation in relation to ovulation and luteal function.
TLDR
Serum PP14 measurements may provide useful information about the endometrium in relation to fertility, and that these measurements during the menstrual cycle may distinguish between ovulatory and anovulatory cycles.
The Corpus Luteum: Determinants of Progesterone Secretion in the Normal Menstrual Cycle
TLDR
The general decrease in progestersone in the latter days of the menstrual cycle appears to be due to a decrease in the progesterone pulse amplitude.
Metabolism of HCG in man.
ABSTRACT The metabolic clearance rate (MCR) of human chorionic gonadotropin (HCG) was determined in normal male and female subjects following the intravenous and intramuscular administration of
The radioimmunoassay of human placental protein 14 (PP14).
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