Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

@article{Varty2005CharacterizationOT,
  title={Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species},
  author={Geoffrey B. Varty and Lynn A. Hyde and Robert A. Hodgson and S. X. Lu and Martha F. McCool and Tatiana M. Kazdoba and Robert A. Del Vecchio and Donald H. Guthrie and Annamarie J. Pond and Michael E. Grzelak and X. Z. Xu and Walter A. Korfmacher and Deen Bandhu Tulshian and Eric M. Parker and Guy A Higgins},
  journal={Psychopharmacology},
  year={2005},
  volume={182},
  pages={132-143}
}
RationalePrevious studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198.ObjectivesThe aim of this study was to examine the effects of Ro64-6198 in anxiety models across three species: rat, guinea pig, and mouse. In addition, the receptor specificity of Ro64-6198 was studied, using the ORL-1 receptor antagonist, J-113397, and ORL-1 receptor knockout (KO) mice. Finally, neurological studies… 

The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

The findings suggest that the effects of Ro 64-6198 on operant lever pressing are mediated by NOP receptors and that larger doses are required to impact operant behavior when compared directly with those that produce antinociception.

Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands

A rather unique behavioral profile since the activation or the blockade of a given neuropeptide receptor produces, in most of the cases, both antidepressant- and anxiolytic-like effects.

Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys

It is demonstrated that Ro 64-6198 produced stimulus effects in monkeys that are distinct from other opioid receptor agonists, but may be somewhat similar to diazepam.

Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis

Evaluating the role of the BST in the functional antagonism between N/OFQ and CRF by examining it at molecular level and in the context of CRF-induced anxiety in the rat suggests that this antagonism may occur within the BST.
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