Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells

@article{Li1999CharacterizationOT,
  title={Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells},
  author={Y. Li and R. Papke and Y. He and W. Millard and E. Meyer},
  journal={Brain Research},
  year={1999},
  volume={830},
  pages={218-225}
}
  • Y. Li, R. Papke, +2 authors E. Meyer
  • Published 1999
  • Biology, Medicine
  • Brain Research
  • The alpha7 nicotinic receptor partial agonist DMXB protected differentiated PC12 cells from NGF+ serum deprivation over a concentration range (1-10 microM) that correlated with activation of protein kinase C. Increased toxicity was observed at a higher concentration of DMXB (30 microM) that did not elevate protein kinase C activity, but did increase tyrosine protein kinase activity. Neuroprotection was blocked with the protein kinase C-inhibitor bis-indolemaleimide, while toxicity was… CONTINUE READING
    α7 Receptor-selective agonists and modes of α7 receptor activation
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    Multiple calcium channels and kinases mediate α7 nicotinic receptor neuroprotection in PC12 cells
    • 50
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