Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells.

  title={Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells.},
  author={Yifei Li and Roger L Papke and Yizhou Joe He and William J. Millard and E. Michael Meyer},
  journal={Brain research},
  volume={830 2},
The alpha7 nicotinic receptor partial agonist DMXB protected differentiated PC12 cells from NGF+ serum deprivation over a concentration range (1-10 microM) that correlated with activation of protein kinase C. Increased toxicity was observed at a higher concentration of DMXB (30 microM) that did not elevate protein kinase C activity, but did increase tyrosine protein kinase activity. Neuroprotection was blocked with the protein kinase C-inhibitor bis-indolemaleimide, while toxicity was… CONTINUE READING


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