Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator.

@article{Suzuki1998CharacterizationOT,
  title={Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator.},
  author={T. Suzuki and K. Hirooka and K. Kanda and H. Uesaka and H. Hirooka and K. Furusawa},
  journal={Biological \& pharmaceutical bulletin},
  year={1998},
  volume={21 7},
  pages={
          704-9
        }
}
The neurochemical effects of SK-946, N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate, were investigated in an attempt to elucidate cognition activating properties. In rat brain cortical membranes and in cloned human receptors expressed in Sf9 cells, SK-946 had submicromolar affinities for muscarinic receptors with a moderate selectivity for M1 (m1) sites. Although no increase in the antagonist (N-methylscopolamine)/agonist (oxotremorine-M) binding ratio was observed, SK-946… Expand
Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors.