Characterization of the nanoscale properties of individual amyloid fibrils.

@article{Smith2006CharacterizationOT,
  title={Characterization of the nanoscale properties of individual amyloid fibrils.},
  author={Jeffrey F Smith and Tuomas P. J. Knowles and Christopher M. Dobson and Cait E. MacPhee and Mark Edward Welland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 43},
  pages={15806-11}
}
We report the detailed mechanical characterization of individual amyloid fibrils by atomic force microscopy and spectroscopy. These self-assembling materials, formed here from the protein insulin, were shown to have a strength of 0.6 +/- 0.4 GPa, comparable to that of steel (0.6-1.8 GPa), and a mechanical stiffness, as measured by Young's modulus, of 3.3 +/- 0.4 GPa, comparable to that of silk (1-10 GPa). The values of these parameters reveal that the fibrils possess properties that make these… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 114 extracted citations

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Mechanics of Materials (Brooks Cole-Thomson

  • J Gere
  • 2003
1 Excerpt

Methods Enzymol 309:429–459

  • A Lomakin, GB Benedek, DB Teplow
  • 1999

Structure and Mechanism in Protein Science ( Freeman , New York )

  • MB Pepys
  • 1999

The Theory of Polymer Dynamics (Oxford

  • M Doi, SF Edwards
  • 1986
2 Excerpts

Theory of Elasticity (Butterworth-Heinemann, Boston)

  • A Kosevich, E Lifshitz, L Landau, L Pitaevskii
  • 1986
1 Excerpt

Similar Papers

Loading similar papers…