Characterization of the nanoscale properties of individual amyloid fibrils.

  title={Characterization of the nanoscale properties of individual amyloid fibrils.},
  author={Jeffrey F Smith and Tuomas P. J. Knowles and Christopher M. Dobson and Cait E. MacPhee and Mark Edward Welland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 43},
We report the detailed mechanical characterization of individual amyloid fibrils by atomic force microscopy and spectroscopy. These self-assembling materials, formed here from the protein insulin, were shown to have a strength of 0.6 +/- 0.4 GPa, comparable to that of steel (0.6-1.8 GPa), and a mechanical stiffness, as measured by Young's modulus, of 3.3 +/- 0.4 GPa, comparable to that of silk (1-10 GPa). The values of these parameters reveal that the fibrils possess properties that make these… CONTINUE READING


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