Characterization of the muscarinic receptor subtypes in the rat urinary bladder.

@article{Monferini1988CharacterizationOT,
  title={Characterization of the muscarinic receptor subtypes in the rat urinary bladder.},
  author={Eugenia Monferini and E. Giraldo and Herbert Ladinsky},
  journal={European journal of pharmacology},
  year={1988},
  volume={147 3},
  pages={453-8}
}
We investigated the nature of the muscarinic receptors present in the rat urinary bladder by performing binding studies with various selective (pirenzepine, AF-DX 116, hexahydrosiladifenidol, benzhexol, 4-diphenyl-acetoxy-N-methyl piperidine methiodide, dicyclomine, secoverine) and classical (N-methylscopolamine, atropine) antagonists. Competition experiments were carried out against [3H]N-methyl scopolamine at 30 degrees C in Na+/Mg2+ HEPES buffer; non-specific binding was determined in the… CONTINUE READING

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