Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants.

@article{Bengtsson2001CharacterizationOT,
  title={Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants.},
  author={Therese Bengtsson and Lisbet Camper and Maximilian Schneller and Evy Lundgren-Akerlund},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2001},
  volume={20 8},
  pages={565-76}
}
Alpha10beta1 is a collagen-binding integrin expressed by chondrocytes [Camper et al. (1998) J. Biol. Chem. 273: 20383-20389]. In the present study, the mouse alpha10 gene was isolated from a sCos1 SVJ library and the genomic structure and chromosomal localization was determined. The alpha10 gene consists of 30 translated exons spanning a region of approximately 18 kb genomic DNA. The sequences of all exon/intron borders follow the consensus "gt-ag" rule. A transcription start site, determined… CONTINUE READING