Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.

@article{Chao2002CharacterizationOT,
  title={Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.},
  author={Jennifer R Chao and Yan G. Ni and Carlos A. Bola{\~n}os and Zia Rahman and Ralph Joseph Dileone and Eric J Nestler},
  journal={The European journal of neuroscience},
  year={2002},
  volume={16 7},
  pages={1284-94}
}
Adenylyl cyclase (AC) type VIII has been implicated in several forms of neural plasticity, including drug addiction and learning and memory. In the present study, we directly examined the role for the transcription factor CREB (cAMP response element binding protein) in regulating ACVIII expression by cloning a 5.2 kilobase region upstream of the translation start site of the mouse ACVIII gene. Analysis of this fragment revealed consensus elements for several transcription factors, including a… CONTINUE READING