Characterization of the molecular mechanisms for p53-mediated differentiation.

  title={Characterization of the molecular mechanisms for p53-mediated differentiation.},
  author={Kristina Chylicki and Mats Ehinger and Helena B. Svedberg and Urban Gullberg},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={11 11},
The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest. Moreover, we and others have shown previously that p53 is a potent mediator of differentiation. For example, expression of ptsp53, a temperature-inducible form of p53, induces differentiation of leukemic monoblastic U-937 cells. The functions of p53 have for long been believed to be dependent on the transactivating capacity of p53. However, recent data show that both p53-induced cell cycle arrest and apoptosis can… CONTINUE READING