Characterization of the minimal DNA-binding domain of the HIV integrase protein.

Abstract

The human immunodeficiency virus (HIV) integrase (IN) protein mediates an essential step in the retroviral lifecycle, the integration of viral DNA into human DNA. A DNA-binding domain of HIV IN has previously been identified in the C-terminal part of the protein. We tested truncated proteins of the C-terminal region of HIV-1 IN for DNA binding activity in… (More)

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@article{Lutzke1994CharacterizationOT, title={Characterization of the minimal DNA-binding domain of the HIV integrase protein.}, author={Ramon A. Puras Lutzke and Cornells Vink and Ronald H. A. Plasterk}, journal={Nucleic acids research}, year={1994}, volume={22 20}, pages={4125-31} }