Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles.

@article{Lai2008CharacterizationOT,
  title={Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles.},
  author={Samuel K Lai and Kaoru Hida and Clive Chen and Justin Hanes},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2008},
  volume={125 2},
  pages={107-11}
}
Recently, 24 nm polymer nanoparticles were found to access a privileged non-degradative intracellular pathway that leads to perinuclear accumulation. Here, we report the intracellular dynamics of vesicles containing polymer nanoparticles within this non-degradative pathway, characterized by clathrin- and caveolae-independent endocytosis, as compared to endosomes originating from classical clathrin-mediated endocytosis. Similar to transport of acidic endosomes and lysosomes, the dynamic… CONTINUE READING

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