Characterization of the interstitial lung and peripheral blood T cell receptor repertoire in smokers

@inproceedings{Korn2004CharacterizationOT,
  title={Characterization of the interstitial lung and peripheral blood T cell receptor repertoire in smokers},
  author={Stephanie Korn and Rainer Wiewrodt and Yvonne C Walz and Kai Helge Becker and Eckhard Mayer and Frank Krummenauer and R. Buhl},
  year={2004}
}
T lymphocytes modulate the pulmonary inflammatory response. Aim of this study was to evaluate the clonality within the interstitial lung and peripheral blood T cell receptor (TCR) repertoire in smokers. Interstitial T lymphocytes were isolated from surplus tissue of 16 pts. (63±9 (±SD) yrs., 11 male) undergoing surgery due to lung cancer (n=15) or emphysema. TCR clonality was assessed by PCR amplification followed by spectratyping. Nearly all TCR of interstitial lung lymphocytes showed… CONTINUE READING