Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cells.

@article{Claudepierre2000CharacterizationOT,
  title={Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal M{\"u}ller glial cells.},
  author={Thomas Claudepierre and C{\'e}cile Dalloz and Dominique Mornet and Kiichiro Matsumura and Jos{\'e}-Alain Sahel and Alvaro Rend{\'o}n},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 19},
  pages={3409-17}
}
The abnormal retinal neurotransmission observed in Duchenne muscular dystrophy patients has been attributed to altered expression of C-terminal products of the dystrophin gene in this tissue. Müller glial cells from rat retina express dystrophin protein Dp71, utrophin and the members of the dystrophin-associated glycoprotein complex (DGC), namely beta-dystroglycan, delta- and gamma-sarcoglycans and alpha1-syntrophin. The DGC could function in muscle as a link between the cystoskeleton and the… CONTINUE READING