Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

@article{McLaurin1997CharacterizationOT,
  title={Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.},
  author={JoAnne McLaurin and Avijit Chakrabartty},
  journal={European journal of biochemistry},
  year={1997},
  volume={245 2},
  pages={355-63}
}
Increasing evidence suggests that Alzheimer beta-amyloid peptides (AAPbeta) may be toxic agents in Alzheimer disease. We investigated the possibility that the toxicity may be the result of peptide-lipid interactions, involving either the cell membrane or the intracellular vesicular system. The interaction of the AAPbeta-(1-40), AAPbeta-(1-42), AAPbeta-(9-25) and AAPbeta-(25-35)-peptides with acidic and zwitterionic phospholipids was investigated by means of circular dichroism, vesicle… CONTINUE READING

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