• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2001
  • DOI:10.1002/jps.1144

Characterization of the interactions between polymethacrylate-based aqueous polymeric dispersions and aluminum lakes.

@article{Nyamweya2001CharacterizationOT,
  title={Characterization of the interactions between polymethacrylate-based aqueous polymeric dispersions and aluminum lakes.},
  author={N Nyamweya and Ketan A Mehta and Stephen W. Hoag},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 12},
  pages={
          1937-47
        }
}
Instability in film coating formulations can arise from interactions between aluminum lake pigments and aqueous polymeric dispersions. The purpose of this study was to characterize the interactions between three polymethacrylate-based aqueous polymeric dispersions (Eudragit RS 30 D, Eudragit L 30 D-55, and Eudragit NE 30 D) and aluminum lakes. Particle size measurements, pH stability profiles, zeta potential measurements, and microscopy were used to study mixed dispersions of the polymeric… CONTINUE READING