Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels.

@article{Wilhelm1991CharacterizationOT,
  title={Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels.},
  author={Doris Wilhelm and Herbert M. Himmel and Ursula Ravens and Thies Peters},
  journal={British journal of pharmacology},
  year={1991},
  volume={104 2},
  pages={483-9}
}
1. In isolated cardiac muscle, submicromolar concentrations of R 56865 (N-[1-[4-(4-fluorophenoxy)-butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) have been shown to attenuate the toxicity of cardiac glycosides. 2. We studied the influence of R 56865 on calcium and sodium currents in single isolated ventricular cardiomyocytes. The effect of R 56865 on action potential and contractile force in the presence of increased sodium load was also tested by exposing papillary muscles to veratridine… CONTINUE READING