Characterization of the interaction of Escherichia coli heat-stable enterotoxin (STa) with its putative receptor on the intestinal tract of newborn calves.

@article{AlMajali2000CharacterizationOT,
  title={Characterization of the interaction of Escherichia coli heat-stable enterotoxin (STa) with its putative receptor on the intestinal tract of newborn calves.},
  author={Ahmad Mahmoud Al-Majali and Elikplimi K. Asem and Carlton H. Lamar and Joseph P. Robinson and Melissa J. Freeman and A. Mahdi Saeed},
  journal={FEMS immunology and medical microbiology},
  year={2000},
  volume={28 2},
  pages={97-104}
}
Enterotoxigenic Escherichia coli (ETEC) induces severe diarrhea in newborn calves through the elaboration of heat-stable enterotoxin (STa). We investigated the distribution and characteristics of the STa-specific receptors on enterocytes and brush border membrane vesicles (BBMVs) prepared from anterior jejunum, posterior jejunum, ileum and colon of newborn calves. We found that density of the receptors and their affinity to STa were higher on enterocytes and BBMVs that were derived from the… CONTINUE READING