Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex.

@article{Niu2000CharacterizationOT,
  title={Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex.},
  author={Hanben Niu and Jiahui Xia and Neal F Lue},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 18},
  pages={6806-15}
}
Telomerase is a ribonucleoprotein that mediates extension of the dG-rich strand of telomeres in most eukaryotes. Like telomerase derived from ciliated protozoa, yeast telomerase is found to possess a tightly associated endonuclease activity that copurifies with the polymerization activity over different affinity-chromatographic steps. As is the case for ciliate telomerase, primers containing sequences that are not complementary to the RNA template can be efficiently cleaved by the yeast enzyme… CONTINUE READING

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