Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358.

@article{Yang2014CharacterizationOT,
  title={Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358.},
  author={Min Yang and Chun-hui Gao and Jialing Hu and Chao Dong and Zheng-Guo He},
  journal={The FEBS journal},
  year={2014},
  volume={281 12},
  pages={2726-37}
}
Toxin-antitoxin (TA) systems play significant roles in the regulation of bacterial growth and persistence, and their functions usually depend on protein-protein interaction between their constituent TA proteins. However, the regulatory mechanisms of these systems, particularly their interaction with other cellular components, are still poorly understood. This study investigated cross-talk between the TA module RelJ/K (Rv3357/Rv3358) and the transcriptional regulator staphylococcal iron… CONTINUE READING