Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections.

@article{He2006CharacterizationOT,
  title={Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections.},
  author={R. He and Dong-chuan Guo and A. Estrera and H. Safi and T. Huynh and Zhengnan Yin and S. Cao and Jing Lin and T. Kurian and L. Buja and Y. Geng and D. Milewicz},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2006},
  volume={131 3},
  pages={
          671-8
        }
}
OBJECTIVE The histopathologic abnormality underlying ascending aortic aneurysm and dissection is medial degeneration, a lesion that is described as the noninflammatory loss of smooth muscle cells and elastic fibers. This study sought to determine whether inflammatory cells are present in medial degeneration and assess any possible contribution of these cells to apoptosis of smooth muscle cells. METHODS Aortic specimens were obtained from patients undergoing prophylactic surgical repair of an… Expand
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Many medial SMCs in AAAs bear markers of apoptosis and signals capable of initiating cell death, which may contribute to the reduction of cellularity and to the impaired repair and maintenance of the arterial extracellular matrix inAAAs. Expand
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TLDR
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