Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

@article{Lund2001CharacterizationOT,
  title={Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry},
  author={Eric T Lund and Robert Mckenna and D. B. Evans and Sandeep Savitaprakash Sharma and W. Rodney Mathews},
  journal={Journal of Neurochemistry},
  year={2001},
  volume={76}
}
Hyperphosphorylated tau is an integral part of the neurofibrillary tangles that form within neuronal cell bodies, and tau protein kinase II is reported to play a role in the pathogenesis of Alzheimer's disease. Recently, we reported that tau protein kinase II (cdk5/p20)‐phosphorylated human tau inhibits microtubule assembly, and tau protein kinase II (cdk5/p20) phosphorylation of microtubule‐associated tau results in dissociation of phosphorylated tau from the microtubules and tubulin… 

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