Characterization of the in vitro conversion of dolichol to dolichoate in bovine thyroid.

@article{Dessel1993CharacterizationOT,
  title={Characterization of the in vitro conversion of dolichol to dolichoate in bovine thyroid.},
  author={G. V. Van Dessel and A. Lagrou and H. Hilderson and W. Dierick},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1167 3},
  pages={
          307-15
        }
}
The enzymic conversion of dolichol into dolichoic acid has been studied in bovine thyroid subcellular fractions using [1-3H]dolichol as a substrate. The presence of conversion activity could be demonstrated in both the mitochondrial- and supernatant fractions. Investigation of cofactor requirements revealed that NAD+ was essential for reaching optimal activity. From kinetic studies Km-values of 3.5-4 microM and 0.29 mM could be calculated for, respectively, dolichol and NAD+ using the… Expand
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