Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses.

@article{Nicholas2002CharacterizationOT,
  title={Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses.},
  author={Benjamin L Nicholas and Frank R Brennan and Jorge L. Martinez-Torrecuadrada and Jos{\'e} Ignacio Casal and William D. Hamilton and Derek R. Wakelin},
  journal={Vaccine},
  year={2002},
  volume={20 21-22},
  pages={2727-34}
}
NIH mice were vaccinated subcutaneously or intranasally with chimaeric cow pea mosaic virus (CPMV) constructs expressing a 17-mer peptide sequence from canine parvovirus (CPV) as monomers or dimers on the small or large protein surface subunits. Responses to the chimaeric virus particles (CVPs) were compared with those of mice immunized with the native virus or with parvovirus peptide conjugated to keyhole limpet haemocyanin (KLH). The characteristics of the immune response to vaccination were… CONTINUE READING
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