Characterization of the hypothermic component of LPS-induced dual thermoregulatory response in rats

@article{Dogan2002CharacterizationOT,
  title={Characterization of the hypothermic component of LPS-induced dual thermoregulatory response in rats},
  author={Muberra Devrim Dogan and Haluk Ataoğlu and Eyup S. Akarsu},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={72},
  pages={143-150}
}
We have previously shown that Escherichia coli O111:B4 serotype lipopolysaccharide (LPS) produced a dual change in rectal temperature (Tb), in which hypothermia preceded fever at subthermoneutral ambient temperature (Tamb; 24-26 degrees C) in rats. In this study, the characteristics of the initial hypothermic response were evaluated. Hypothermia was significant when LPS (50 microg/kg, i.p.) was injected at thermoneutral Tamb (30 degrees C). There was no heat loss through tail skin during… CONTINUE READING

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