Characterization of the hypotensive action of dopamine receptor agonists fenoldopam and quinpirole in anaesthetized rats.

Abstract

The present study was designed to examine the cardiovascular actions of fenoldopam, a DA1-receptor agonist, and quinpirole, a DA2 receptor agonist, in pentobarbital-anaesthetized rats. Fenoldopam (20, 40 and 80 micrograms/kg) produced short lasting decreases in blood pressure accompanied by tachycardia. Quinpirole (20 and 80 micrograms/kg) caused… (More)

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