Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.

@article{Uyama2009CharacterizationOT,
  title={Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.},
  author={Toru Uyama and Xing-Hua Jin and Kazuhito Tsuboi and Takeharu Tonai and Natsuo Ueda},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1791 12},
  pages={1114-24}
}
Tazarotene-induced protein 3 (TIG3) and HRAS-like suppressor family 2 (HRASLS2) exhibit tumor-suppressing activities and belong to the lecithin retinol acyltransferase (LRAT) protein family. Since Ca(2+)-independent N-acyltransferase and H-rev107 (another tumor suppressor), both of which are members of the LRAT family, have been recently reported to possess catalytic activities related to phospholipid metabolism, we examined possible enzyme activities of human TIG3 and HRASLS2 together with… CONTINUE READING
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